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KMID : 0620920070390050673
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Experimental & Molecular Medicine
2007 Volume.39 No. 5 p.673 ~ p.678
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Low-density lipoprotein protects Vibrio vulnificus-induced lethality through blocking lipopolysaccharide action
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Park Kwang-Hyun
Kim Jong-Suk
Lee Young-Rae
Moon Young-Jae
Hur Hyun
Choi Yun-Hee
Kim Cheon-Hyeon
Kim Uh-Hyun
Song Eun-Kyung
Yoo Wan-Hee
Lee Chang-Seop
Kim Byeong-Soo
Lee Sung-Ho
Ryu Phil-Youl
Han Myung-Kwan
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Abstract
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Lipoprotein plays a role in the host defense against bacterial infection, and its serum level has been demonstrated to be an important prognosis factor of survival. We have previously demonstrated that LDL directly inactivates the hemolytic activity of Vibrio vulnificus cytolysin (VVC) in vitro. The object of this study was therefore to examine whether the LDL-mediated inactivation of VVC leads to protection against lethal infection of V. vulnificus in vivo, using wild and VVC-deficient V. vulnificus strains. Unexpectedly, we found that LDL protects mouse lethality induced by VVC-deficient as well as wild V. vulnificus strain. We also demonstrated that LDL blocks V. vulnificus LPS-induced lethality in mice. These results suggest that LDL preferentially act on endotoxin rather than exotoxin in the protection against V. vulnificus-induced mice lethality.
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KEYWORD
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endotoxemia, lipopolysaccharides, lipoproteins, LDL, Vibrio vulnificus, vvP protein, Vibrio vulnificus
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